Some medications can interact with Tadalista and increase the risk of priapism. For instance, the use of nitrates (medications for chest pain) or alpha-blockers (used for high blood pressure or prostate issues) in combination with tadalafil may amplify its effects on blood flow, raising the risk of prolonged erections. Additionally, some antidepressants, antipsychotics, and antihypertensive drugs can interfere with blood circulation and heighten the likelihood of priapism.